Transdermal Drug Delivery, Second Edition, Revised and by Richard H. Guy, Jonathan Hadgraft

By Richard H. Guy, Jonathan Hadgraft

Thoroughly revised, the second one version of Transdermal Drug supply offers discussions of the main matters pertinent to transdermal drug supply. masking the intensity and breadth of the sector, from actual chemistry and evaluation of drug permeability to on hand enhancement applied sciences, to regulatory approval, the booklet examines issues essential to the serious assessment of a drug candidate's power for supply around the epidermis. It describes tips on how to ensure the transdermal permeability of gear, how rationally to pick applicants for transdermal supply, easy methods to decide upon chemical and/or actual the right way to increase pores and skin shipping, and the way to unravel regulatory matters.

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Extra info for Transdermal Drug Delivery, Second Edition, Revised and Expanded (Drugs and the Pharmaceutical Sciences)

Example text

4% of the variability in log P cw is explained by variation in log K ow and MW. 4). 6% of the variability in log P cw is explained by variation in log K ow and MW. If we compare Eqs. (2) and (4) and Eqs. (3) and (5), we see that the adjustment for ionization reduces the variability of permeability coefficients in the Flynn database and improves predictability. The statistics change only slightly because there are other sources of variability, and only a few compounds in the Flynn database are partially ionized.

67. 68. 69. 70. 71. to the use of excised human skin for assessing in vitro percutaneous absorption. Toxicology in Vitro 1998; 12(4):423–430. MP Carver, PL Williams, JE Riviere. The isolated perfused porcine skin flap. III. Percutaneous absorption pharmacokinetics of organophosphates, steroids, benzoic acid, and caffeine. Toxicology and Applied Pharmacology 1989; 97(2):324–337. JE Riviere, BH Sage, NA Monteiro-Riviere. Transdermal lidocaine iontophoresis in isolated perfused porcine skin. Journal of Toxicology—Cutaneous and Ocular Toxicology 1989; 8(4):493–504.

International Journal of Pharmaceutics 1982; 11:119–129. 29. RH Guy, J Hadgraft, HI Maibach. Percutaneous absorption in man: a kinetic approach. Toxicology and Applied Pharmacology 1985; 78(1):123–129. 30. RH Guy, J Hadgraft. The prediction of plasma levels of drugs following transdermal application. Journal of Controlled Release 1985; 1:177–182. 31. RH Guy, J Hadgraft. A theoretical description of the effects of volatility and substantivity on percutaneous absorption. International Journal of Pharmaceutics 1984; 18:139–147.

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