The Mathematical Principles Underlying Newton's Principia by D. T. Whiteside

By D. T. Whiteside

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Tatard-Leitman, Michael J. Gandal, Gregory C. Carlson and Steven J. Siegel Translational Neuroscience Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA USA 1. Introduction Schizophrenia a complex neuropsychiatric disorder, is characterized by core impairments including positive symptoms (hallucinations, delusions), negative symptoms (blunted affect, alogia, social deficits, anhedonia, avolition), as well as persistent neurocognitive deficits (memory, concentration, and learning).

1980). , 2008b). , 2008). Numerous studies have also investigated evoked and induced gamma oscillatory activity in schizophrenia. , 2010). , 2008). , 2009). , 2005). , 2006). Interestingly, these findings were replicated in medication-naïve and chronically medicated patients. However like other frequencies, contradictory and negative finding exists. Thus, few studies report an augmentation in evoked beta activity, which may be due to methodological or analytical differences (for review see (Uhlhaas and Singer, 2010).

G. , 2000). Peaking between 100 and 225ms, MMN is a difference wave between responses to frequent and deviant stimuli. , 2009). P300. Probably the most extensive studied long-latency ERP component is the P300 (also termed P3), a time-locked positive deflection emerging 250 ms to 500 ms after attending stimulus. First described by Sutton et al. in 1965, P300 is thought to reflect an information processing cascade when attentional and memory mechanisms are engaged (Polich, 2007). Although related to the process of sensory stimulus mismatch detection, the P300 component represents an attention-driven memory comparison process in which every incoming stimulus will be revised to detect possible stimulus feature modifications.

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