The Glycoconjugates. Glycoproteins, Glycolipids and by Martin I. Horowitz, Ward W. Pigman
By Martin I. Horowitz, Ward W. Pigman
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Extra info for The Glycoconjugates. Glycoproteins, Glycolipids and Proteoglycans
1981). The importance of glycosylation for proper protein foldings has also been demonstrated by Chu et al. (1978) in the case of yeast invertase. These workers were able to detect differences in the physical properties of the normal and carbohydrate-depleted forms of the enzyme only after denaturation and subsequent renaturation. These data indicate that some glycoproteins require the presence of the large Glc3Man9GlcNAc2 oligosaccharide at the time of folding. Since high-mannose chains appear to be the most primitive forms of oligosaccharides, these glycoproteins may have evolved with the large high-mannose unit assuming an important role during the initial folding.
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