Research Advances in Alcohol and Drug Problems by Robert M. Post (auth.), Yedy Israel, Frederick B. Glaser,

By Robert M. Post (auth.), Yedy Israel, Frederick B. Glaser, Harold Kalant, Robert E. Popham, Wolfgang Schmidt, Reginald G. Smart (eds.)

Over the decade the realm has skilled a growing to be curiosity in difficulties linked to the nonmedical use of substances. This curiosity has corresponded to a true development within the volume, range, and social impression of using alcohol and medicine in lots of societies. hence, the quantity of analysis and writing almost about drug difficulties has drastically elevated, and it has develop into very tricky for one person to maintain with all of the correct literature. there's hence an acute desire within the box for serious experiences that verify present advancements, and the current sequence is meant to fill this want. The sequence isn't really to be an "annual evaluate" within the ordinary experience. the purpose isn't to hide the entire paintings pronounced in the course of the previous 12 months with regards to a hard and fast choice of themes. relatively, it's to provide every year evaluative papers on subject matters within which sufficient fresh development has been made to change the overall scope in a selected region. because of the multidisciplinary nature of difficulties of drug use and dependence, the papers released in each one quantity should be drawn from numerous disciplines. although, a few volumes could be dedicated to one partic­ ular challenge, with person experiences and papers analyzing quite a few points of it. The composition of the editorial board and the foreign advisory board displays those pursuits. The editors are contributors of the senior clinical employees of the dependancy examine beginning of Ontario.

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1975). Most interestingly, Short and Shuster (1976) reported that brain dopamine and norepinephrine were reduced 85% and 50% of normal in B6AF)/J mice. These depletions persisted for more than 25 days and were associated with persistent behavioral sensitization to the effects of amphetamine. ) In A/J mice there were no dopamine and norepinephrine depletions and no evidence of behavioral sensitization to the effects of amphetamine. Short and Shuster suggested that these persisting depletions of brain catecholamines could be associated with the sensitization phenomenon.

1977) also noted greater effects of environmental context on cocaine- vs. amphetamine-induced stereotypies. X 9 days . - . in Home Cage ...... J ~ 40 -----f------f------t -----1 40 Figure 5. Effect of home cage vs. activity meter cage in cocaine-treated rats. p. once daily) in the activity meter cage show significantly greater activity than those treated with the same dose in their home cage and challenged with cocaine in the activity meter cage on days 10 and 13. Note the increased activity in the homecage-treated animals following their second cocaine injection in the meter (day 13 compared to day 10).

For example, Wood suggested that the rate of tolerance development to ethanol is "in part dependent on the amount of drug-induced impairment experienced in the test environment and not on the presence of the drug alone" (Wood, 1977, p. 71). The effect of environmental context has also been demonstrated in relation to morphine tolerance (Siegel, 1977). , 1978; Pearl and Seiden, 1979). Woolverton et ai. (1978) reported that the development of tolerance to cocaine was contingent on the relationship of the time of cocaine injection to availability of a sweetened condensed milk solution.

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