Pharmacology of Purine and Pyrimidine Receptors by Kenneth A. Jacobson and Joel Linden (Eds.)

By Kenneth A. Jacobson and Joel Linden (Eds.)

This is often an summary of the fast-moving box of purinergic signalling via adenosine and ATP receptors. Authors are the prime specialists of their fields subject material is critical for figuring out tissue safety material is of severe curiosity for brand spanking new drug improvement

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Journal of Medicinal Chemistry, 53(4), 1799–1809. , & Abagyan, R. (2010). Structure based prediction of subtypeselectivity for adenosine receptor antagonists. Neuropharmacology, 60(1), 108–115. , Lam, P. , & Abagyan, R. (2010). GPCR 3D homology models for ligand screening: Lessons learned from blind predictions of adenosine A2A receptor complex. Proteins, 78(1), 197–211. , & Gouaux, E. (2006). Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins.

This pattern was predicted using solvent thermodynamics in which the smaller substituents occupy space containing stable waters, whereas the longer substituents compensate for this by also displacing unstable waters as the ligands extend out of the binding site. IV. Binding Selectivity Across the ARs _______________________________________________________ The AR family represents a clear example of a family of closely related GPCRs activated by a single endogenous ligand (adenosine). , 2009). However, the functional importance of ARs in a wide range of physiological functions across numerous tissues imposes a clear need for subtype selectivity for both AR agonists and antagonists as candidate drugs (Jacobson & Gao, 2006).

2008). 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. Journal of Medicinal Chemistry, 51(15), 4449–4455. , & Tuccinardi, T. (2008). Molecular modeling of adenosine receptors: New results and trends. Medicinal Research Reviews, 28(2), 247–277. Marti-Renom, M. , Stuart, A. , & Sali, A. (2000). Comparative protein structure modeling of genes and genomes. Annual Review of Biophysics and Biomolecular Structure, 29, 291–325. 38 Lane et al. , Brooks, C. , Dixon, J.

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