Nitric Oxide in the Nervous System (Neuroscience by Stephen R. Vincent, Peter Jenner

By Stephen R. Vincent, Peter Jenner

The fuel nitric oxide (NO) has burst upon neuroscience just recently, and but it has permeated into nearly each road of present learn. the original homes of this novel messenger have revolutionized our method ofthinking approximately neurotransmission. those particular homes have additionally lead neuroscientists to invoke NO to give an explanation for many formerly unexplained phenomena in neurobiology. thankfully, the advance of diverse pharmacological brokers is now permitting thesehypotheses to be confirmed. This quantity will supply a synopsis of what's referred to now approximately NO. How and the place NO is produced, the way it acts on the molecular point to turn on the synthesis of cGMP, and the potential ambitions of cGMP within the frightened process are reviewed. the jobs of theNO/cGMP sign transduction pathway within the valuable and peripheral fearful platforms, in glial cells, and in neuropathology are then explored. jointly, those experiences will result in additional paintings explaining the numerous features of NO. Key beneficial properties * Describes how and why NO is produced within the anxious process * Examines all that's recognized of NOs function as a neurotransmitter * Explores mobile activities and physiological roles within the mind and peripheral fearful method Covers NOs molecular synthesis to its position in neuropathology

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M. H. (199l a) Neuron 7, 615--624. R. H. (1991b) Nature 351, 714-718. D. H. (1992)37. BioL Chem. 267, 10976-10981. Brtine, B. G. (1991) Biochem. Biophys. Res. Commun. 181, 921-926. Briining, G. (1993)37. Neurosd. Res. 36, 580-587. E. & Ignarro, LJ. (1993) Circ. Res. 73, 808-812. Busconi, L. & Michel, T. (1993)J. Biol. Chem. 268, 8410-8413. G. K. (1992) Immunol. 149, 2736-2741. , Lepoivre, M. P. 7. Chromatogr. 539, 433-44-1. , Lepoivre, M. P. (1993) Biochem. Biophys. Res. Commun. 196, 1558-1565.

36, 491-496. W. & Stuehr, D 0. Eng. News 71, 26-38. , Zimmermann, M. & Herdegen, T. (1993) Neurosd. Lett. 50, 169-173. , Heller, M. & Murad, E (1991) Proc. Natl. Acad. &'i. USA 88, 1788-1792. J. (1991) Annu. Rev. Pharmacol. Toxicol. 31, 177-203. E. E (1993) Biochemistry 32, 8512-8517. L. & Chess-Williams, R. (1988) Nature 336, 385-388. L. (1993)07. Pediatr. 123, 76-79. L. & Kaufman, S. (1991) Proc. Natl. Acad. &i. USA 88, 7091-7095. , Ishii, K. & Murad, E (1990) FASEB 07. 4, 1494-1500. J. 7. Immunol.

1992), specific activity was rather low ('--15 nmol L-citrulline min -1 mg-I), 24 Biochemistry and molecularpharmacologyof nitric oxide synthases suggesting instability of NOS in detergent or removal of an essential cofactor during purification. , 1993), demonstrating that membrane association of this isozyme is due to post- or co-translational modification. , 1993). e. , 199 l a). 7) or 150 kDa (rat peritoneal macrophages). 5 ~tmol g-citrulline min-I mg-~. , respectively. , 199 lb). , 1992), suggesting that all NOS isoforms require bound calmodulin for activity.

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