New Insights on Antiviral Probiotics: From Research to by Imad Al Kassaa

By Imad Al Kassaa

This ebook makes a speciality of probiotics with antiviral actions. The "antiviral probiotic" is a brand new idea in scientific sciences. lately, experiences have proven that antiviral probiotics can struggle or hinder viral infections in lots of methods. The immunomodulation of mucosal immunity, construction of antiviral compounds, virus trapping and the use thereof as vaccination vectors are the crucial modes of motion of antiviral probiotics. the writer dedicates a whole bankruptcy of the ebook to discussing the equipment and methods used to evaluate the antiviral job of probiotic traces and their metabolites.

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A complete genome sequence of B. longum subsp. Infantis CECT 7210 was conducted in 2015 by [170]. This strain had previously showed, in a study conducted by Muñoz et al. [153], a direct effect on rotavirus strains in both in vitro (MA-104 and HT-29 cell culture) and in vivo (McN mouse model) experiments. The immunomodulatory mechanism was the main effect of this strain [153]. After complete sequencing of the B. longum subsp. Infantis CECT 7210 strain, they reported that there were 360 more elements (genes) in this strain compared with the complete genome sequence of B.

4 Role of Probiotics in Gut Microbiota In addition to the immunomodulatory effect of probiotics, these beneficial bacteria have several mechanisms to defend gut pathogens and infections. In the previous part, the studies have shown that the composition of the intestinal microbiota can help EnVs to persist and sometimes amplifies their infectivity. Remarkably, the presence of Gram-negative bacteria in the microbiota is essential to save the infectivity of EnVs. Therefore, changing the intestinal microbiota composition seems to be effective in preventing or inhibiting enteric viral infection.

Norovirus gastroenteritis in a birth cohort in Southern India. PLoS One. 2016;11:e0157007. 1371/journal. 0157007. 95. Joshi SS, Howell AB, D’Souza DH. Reduction of enteric viruses by blueberry juice and blueberry proanthocyanidins. Food Environ Virol. 2016;8:235–243. 1007/s12560-016-9247-3. 96. Buesa J, Rodrı’guez-Dı’az J. Molecular virology of enteric viruses (with emphasis on caliciviruses). Viruses foods. New York: Springer; 2006. p. 43–100. 97. Karst SM. The influence of commensal bacteria on infection with enteric viruses.

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