Genetic Mosaics and Chimeras in Mammals by Karl Illmensee (auth.), Liane B. Russell (eds.)

By Karl Illmensee (auth.), Liane B. Russell (eds.)

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The enzyme was scored by electrophoresis of serial dilutions, as described by Klebe (1975). The proportion of one or other allozyme can be derived from the number of dilution steps separating the last visible bands of the two. This method proved to be highly repeatable, nearly always giving the same reading on repeated runs. Nine organs or tissues were studied: they are listed in Table 1. The C ++ L chimaeras were killed for the enzyme assays when they were 10--12 months old, but their body weights analysed were those at 6 weeks of age.

A. Moore. 1953. Testicular tumors -A clinico-pathologic study. Cancer 6: 427-454. Edidin, M. and L. R. Gooding. 1975. Teratoma-defined and transplantation antigens in early mouse embryos. In, Teratomas and Differentiation, M. I. Sherman and D. Solter,:Eds. Academic Press, New York, pp. 109-121. Elsevier, S. , R. S. Kucherlapati, E. A. Nichols, R. P. Creagan, R. E. Giles, F. H. Ruddle, K. Willecke, and J. K. McDougall. 1974. Assignment of the gene for galactokinase to human chromosome 17 and its regional localization to band q 21-22.

B. 1974b. Neoplasms, differentiations and mutations. American Journal of Pathology 1l: 103-118. Pierce, G. B. and T. F. Beals. 1964. The ultrastructure of primordial germinal cells of the foetal testis and of embryonal carcinoma cells in mice. Cancer Res. 24: 1553-1567. 25 TERATOCARCINOMA CELLS IN CHIMERIC MICE Sherman, M. I. and D. Solter, Eds. 1975. tiation. Academic Press, New York. Teratomas and Differen- Simpson, J. L. and G. Photopulos. 1976. The relationship of neoplasia to disorders of abnormal sexual differentiation.

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