Frontiers in Neuropsychiatric Research by Earl Usdin, Menek Goldstein, Arnold Friedhoff, Anastasios
By Earl Usdin, Menek Goldstein, Arnold Friedhoff, Anastasios Georgotas (eds.)
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Naunyn Schmiedeberg's Arch. , Pole, P. and Schaffner, R. (1981). General pharmacology and neuropharmacology of benzodiazepine derivatives. Handbook of Exp. , 55, II Hirata, F. and Axelrod, J . (1980). Phospholipid methylation and biological signal transmission. Science, 209:1082-1090 Iyengar, R. and Birnbaumer, L. (1979). Coupling of the glucagon receptor to adenylyl cyclase by GDP : Evidence for two levels of regulation of adenylyl cyclase. Proc. Natl. Acad. Sci. , and Spindel, E. (1981). Immunohistochemical support for three putative transmitters in one neuron : Coexistence of 5-hydroxytryptamine, substance P and thyrotropin releasing hormone-like immunoreact ivity i n medullary neurons projecting to the spinal cord.
L. (1978). Mode of action of antidepressant drugs. Biochem. , 27:257 31 Regional variations in 5-HT receptor populations and in 3H-imipramine binding sites in their responses to chronic antidepressant treatment K Fuxe 1, S-O Ogren", L F Agnati", F Benfenati? , L Cavicchioli'' , B Fredholm 1 , K Andersson 1 , C Farabegoli? and P Eneroth" SUMMARY Chronic treatment in clinically relevant doses with typical and atypical antidepressant drugs (desipramine, imipramine, alaproclate and zimelidine) demonstrates marked regional differences in the adaptive changes taking place in 3H-5-HT binding sites , in the ~H-spiperone binding sites linked to 5-HT receptors and in the 3H-imipramine binding sites linked to the 5-HT uptake mechanism.
2. Figure 2 Schematic illustration of the distribution of SP immunoreact ive nerve cell bodies in a sagittal and parasagittal plane of the rat brain based on the wo r k of Ljungdahl, H5kfelt and colleagues (1978). CT = cottaOSl11lller 5HT CT IRESPONSEI POSSIBLE SITE ()' ACTKfl OF ANTIDEPRESSANTS Figure 3 Schematic illustration of mechanisms operating in 5-HT neurotransmission and on the possible sites of action of antidepressant drugs. The figure illustrates that antidepressant compounds may not only modulate presynaptic and postsynaptic 5-HT mechanisms, but also mechanisms for 5-HT comodulator release and receptors for 5-HT comodulators located in the postsynaptic membrane.