Ciba Foundation Symposium 196 - Growth Factors as Drugs for by CIBA Foundation Symposium

By CIBA Foundation Symposium

Degeneration of sensory receptors or of the nerves innervating them results in a sensory deficit. a variety of recommendations were attempted for selling regrowth of sensory receptors, rather within the eye and ear. the most recent facts from experimental stories in animals are offered within the ebook together with functions of BDNF and CNTF within the eye and epidermal progress consider the ear.


Show description

Read Online or Download Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders PDF

Similar mammals books

Red Panda: Biology and Conservation of the First Panda (Noyes Series in Animal Behavior, Ecology, Conservation, & Management)

Crimson Panda: Biology and Conservation of the 1st Panda offers a broad-based assessment of the biology of the purple panda, Ailurus fulgens. A carnivore that feeds nearly solely on vegetable fabric and is coloured chestnut crimson, chocolate brown and cream instead of the anticipated black and white. This booklet gathers all of the info that's to be had at the pink panda either from the sphere and captivity in addition to from cultural features, and makes an attempt to respond to that the majority primary of questions, "What is a crimson panda?

Wild Mammals in Captivity: Principles and Techniques for Zoo Management, Second Edition

Zoos, aquaria, and flora and fauna parks are very important facilities of animal conservation and administration. for almost fifteen years, those associations have depended on Wild Mammals in Captivity because the crucial reference for his or her paintings. Now the e-book reemerges in a totally up to date moment version. Wild Mammals in Captivity provides the most up-tp-date considering and perform within the care and administration of untamed mammals in zoos and different associations.

Social Predation. How group living benefits predators and prey

The vintage literature on predation dealt virtually completely with solitary predators and their prey. Going again to Lotka-Volterra and optimum foraging conception, the speculation approximately predation, together with predator-prey inhabitants dynamics, was once constructed for solitary species. a number of effects of sociality for predators were thought of just recently.

Gene Therapy for Neurological Disorders: Methods and Protocols

This quantity presents a transparent and particular roadmap of the way to layout and execute a gene remedy scan for you to receive constant effects. Chapters during this publication disseminate bits of unknown details which are vital to think about throughout the process experimentation and may resolution questions comparable to: What supply car do you utilize?

Extra resources for Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

Example text

Kuplun: We don’t know. Rafl: What about in in vitro experiments? If you give a pulse of N G F for an hour and then remove it, is it still effective? Kuplun: Our main models have been in PC12 cells and 3T3 cells expressing Trk. There, NGF-induced TrkA tyrosine phosphorylation persists only for a few hours. So in vivo there’s a marked difference in what we see. Ruff; Presumably then, there’s a pool that stays around, even if no one has found it. Kaplun: Or it could be that in vivo there’s a desensitized receptor; or that the phosphatases that normally take those tyrosine phosphates off are not functioning.

Consequently, the motor neuron now innervates hundreds more endplates than normal. Over time, as you begin to drive this over-compensated neuronal population, the neuron simply gets ‘tired’ and becomes gradually ineffective. The projections tend to retract, the muscle weakens and deteriorates, there is a loss of function and the motor neuron dies. We have utilized the same models and rationale used for ALS to suggest utility of rhIGF-1 in post-polio. In the current trial that we are considering on postpolio, one challenge we face is that to show a positive clinical benefit will require six months to a year of dosing.

J Neurobiol 25~759-766 Neff NT, Prevette D, Houenou LJ et al 1993 Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival. J Neurobiol 24: 1578-1 588 Rinderknecht E, Humbel R E 1978 Amino acid sequence of human insulin-like growth factor 1 and its structural homology with proinsulin. J Biol Chem 235:2769-2776 Rosenthal SM, Hsiao D, Cheng ZQ, Silverman LA 1994 Insulin-like growth factors and muscle cell differentiation. In: Baxter RC, Gluckman PD, Rosenfeld R G (eds) The insulin-like growth factors and their regulatory proteins: proceedings of the third international symposium on insulin-like growth factors, Sydney, February 1994.

Download PDF sample

Rated 4.45 of 5 – based on 17 votes