Bipolar Disorder: The Upswing in Research and Treatment by Colm McDonald, Katja Schulze, Robin Murray, Padraig Wright
By Colm McDonald, Katja Schulze, Robin Murray, Padraig Wright
This ebook specializes in the new surge in study into the pathogenesis and therapy of bipolar illness, and seriously analyses the facts aiding a number of the traditional critiques concerning the ailment. Chapters by means of best easy technological know-how and scientific researchers from North the USA and Europe deal with concerns together with the very nature of the affliction (psychological sickness or mind disease), the function of genetics, the function of cortisol, and the consequences of long term remedy. in response to lectures provided as a part of the second one eu beginning for Psychiatry on the Maudsley (EFPM) assembly, this publication will stimulate dialogue and debate on novel perspectives and may query the dogmas of latest perform.
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Additional info for Bipolar Disorder: The Upswing in Research and Treatment (European Foundation for Psychiatry at the Maudsley)
Presented at the Society for Neuroscience Meeting, Orlando, FL: 2–7 November, 2002. Kaur S, Sassi R, Axelson D et al, Anatomical MRI study of cingulate cortex in adolescent bipolar patients. Biol Psychiatry 2003; 53:72S. Doris A, Belton E, Ebmeier KP et al, Reduction of cingulate gray matter density in poor outcome bipolar illness. Psychiatry Res 2004; 130:153–159. Lyoo IK, Kim MJ, Stoll AL et al, Frontal lobe gray matter density decreases in bipolar I disorder. Biol Psychiatry 2004; 55:648–651.
Lancet 2000; 356:1241–1242. Sassi RB, Nicoletti M, Brambilla P et al, Increased gray matter volume in lithium-treated bipolar disorder patients. Neurosci Lett 2002; 329:243–245. McDonald C, Bullmore E, Sham P et al, Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: a computational morphometry study. Br J Psychiatry in press. Tkachev D, Mimmack ML, Ryan MM et al, Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 2003; 362:798–805.
19,20 These findings suggest deficits in the recognition of emotive stimuli, including negative facial expressions, in euthymic individuals with bipolar disorder and those in a mood episode. There has been limited examination in individuals with bipolar disorder of the neural mechanism underlying this abnormality in processing emotional stimuli. Instead, studies in individuals with the disorder have focused upon the examination of neural responses during rest and performance of executive and memory tasks.