Biology of the Mouse Histocompatibility-2 Complex: by Jan Klein (auth.)

By Jan Klein (auth.)

Somewhere I heard a narrative of a bridge and a painter. The bridge used to be huge, immense and used to be made all of steel, and the painter's activity used to be to maintain it from rusting. He could begin at one finish and slowly continue, daily, month by way of month, towards the opposite finish, portray the bridge. yet no faster may he end with the portray than the bridge may start to rust back. The rust, too, may commence at one finish and slowly continue towards the opposite finish, systematically destroying the painter's recreation. And so the painter might go back to the place he had all started, and start portray back, slowly continuing towards the opposite finish of the bridge, continuously only one step sooner than the rust. And if the tale is right, the painter may nonetheless be portray that bridge-a glossy Sisyphus! in the course of the writing of this publication, the tale of the painter and his bridge saved coming to brain. the sector the publication covers has been constructing so swiftly that, just like the painter, I too needed to go back to the place I had began and struggle the rust of obsolescence. yet in contrast to the painter, I had a closing date to fulfill, which constituted some degree of no go back. And so, sending off this manuscript, i've got no selection yet to observe the culmination of my activity be overtaken by means of the rust.

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Additional resources for Biology of the Mouse Histocompatibility-2 Complex: Principles of Immunogenetics Applied to a Single System

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T C = BALB/c origin. t B = C57BL/6 origin. 3. Analysis of traits dependent on replicative observations. Genetics of certain traits (for example, virus resistance) is difficult to determine on segregating populations because more than one mouse of the same genotype is required for measurement of such traits. The RI strains, in which a selected number of F 2 segregants can be replicated at will, may circumvent this difficulty. 4. Detection of linkage. If a new gene shows the same SDP as a gene already known, the two genes may be linked.

Green and Doolittle 1963, Snell and Bunker 1965, E. Green 1966), the simplest of which is the NX backcross system. The principle of the NX system is explained in Fig. 2-4, using as an example strains B 10 (background strain) and A (donor strain). A congenic line begins with a crossing of the two strains and backcrossing of the (BlOxA)F 1(= NI) hybrid to the background strain. The resulting N2 generation is typed with BIO anti-A (H-2 b anti-H-r) antiserum, the negative animals (H-2 b/H-2 b) are discarded, and the positive animals (H-2"/ H-2Q) are backcrossed again to the background strain.

Taylor et al. 1973). However, even the lines that meet the criterion do not provide absolute assurance that all differences have been eliminated. Currently available CR lines differing in the B-2 complex are listed in Table 2-8; a complete list of all mouse CR lines can be found elsewhere (Klein 1973b). Table 2-8. C-H-2b. CA(MS06) B10. A(SR) (Continued) 37 The Mouse and Its Forms Table 2-8. S(8R) iaI j ja k m mI 01 02 p pa q r s sqI sq2 tI t2 t3 14 It v wI w2 w3 w4 w5 w6 yI y2 ? C. Recombinant Inbred (RI) Strains "RI strains are those which have been derived from the cross of two unrelated but highly inbred progenitor strains and which have been maintained independently under a regimen of strict inbreeding since the F 2 generation" (Bailey 1971).

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