Bioinformatics: Managing Scientific Data (The Morgan by Zoe Lacroix, Terence Critchlow

By Zoe Lacroix, Terence Critchlow

Lifestyles technology info integration and interoperability is likely one of the so much difficult difficulties dealing with bioinformatics this present day. within the present age of the existence sciences, investigators need to interpret many sorts of data from various resources: lab tools, public databases, gene expression profiles, uncooked series strains, unmarried nucleotide polymorphisms, chemical screening info, proteomic information, putative metabolic pathway types, etc. regrettably, scientists aren't presently capable of simply determine and entry this knowledge as a result number of semantics, interfaces, and knowledge codecs utilized by the underlying info resources. Bioinformatics: dealing with clinical information tackles this problem head-on through discussing the present methods and diversity of platforms on hand to aid bioinformaticians with this more and more advanced factor. the center of the publication lies within the collaboration efforts of 8 distinctive bioinformatics groups that describe their very own targeted methods to facts integration and interoperability. every one procedure gets its personal bankruptcy the place the lead participants supply important perception into the categorical difficulties being addressed by way of the procedure, why the actual structure used to be selected, and information at the system's strengths and weaknesses. In ultimate, the editors supply very important standards for comparing those platforms that bioinformatics execs will locate necessary. * presents a transparent review of the state of the art in info integration and interoperability in genomics, highlighting a number of platforms and giving perception into the strengths and weaknesses in their diversified methods. * Discusses shared vocabulary, layout matters, complexity of use situations, and the problems of moving current facts administration methods to bioinformatics platforms, which serves to attach laptop and lifestyles scientists. * Written via the first participants of 8 respected bioinformatics platforms in academia and together with: BioKris, TAMBIS, K2, GeneExpress, P/FDM, MBM, SDSC, SRS, and DiscoveryLink.

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Additional info for Bioinformatics: Managing Scientific Data (The Morgan Kaufmann Series in Multimedia Information and Systems)

Sample text

Org. ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ...................................... approach, interactions between different domain ontologies are critical in future development. For example, brain ontology will inevitably relate to ontologies of other anatomical structures or at the molecular level will share ontologies for genes and proteins [38]. A sample collection of ontology resources in life science is listed in the Appendix. A consistent vocabulary is critical in querying across multiple data sources.

However, the most striking feature of data in life science is not its volume but its diversity and variability. 1 Diversity The biological data sets are intrinsically complex and are organized in loose hierarchies that reflect our understanding of the complex living systems, ranging from genes and proteins, to protein-protein interactions, biochemical pathways and regulatory networks, to cells and tissues, organisms and populations, and finally the ecosystems on earth. 2 Challenges Faced in the Integration of Biological Information Notional representation of the vast and complex biological world.

Thus, accelerating progress now requires multidisciplinary teams to conduct integrated approaches. Thus, in silico discovery, that is, experiments carried out with a computer, is fully complementary to traditional wet-laboratory experiments. One could say that an information infrastructure, coupled with continued advances in experimental methods, will facilitate computing an understanding of biology. 2 AN INFORMATION INTEGRATION ENVIRONMENT FOR LIFE SCIENCE DISCOVERY Biological data sources represent the collective research efforts and products of the life science communities throughout the world.

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