Best Practice & Research Clinical Haematology Volume 24, by W. Fibbe

By W. Fibbe

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Extra info for Best Practice & Research Clinical Haematology Volume 24, Issue 1 March 2011

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Although phenotypically distinct MSC subsets exhibit properties, which are unique with regard to their proliferation and differentiation capacity, there is still a broad heterogeneity at the clonal level [6]. Heterogeneity of individual MSC clones has been reported by several groups, who demonstrated that the developmental and proliferative potential was highest in cells giving rise to large colonies, whereas small-sized colonies were derived from cells with limited differentiation and proliferation capacity [6].

We therefore propose an extended model, in which STRO-1þCD56þTNAPÀ/dim MSC represent an immature precursor with multi-lineage differentiation capacity. Cells committed to the chondrocyte lineage diverge at very early (CD56þ) stages of MSC differentiation. This chondrogenic potential, which is rapidly lost upon differentiation into TNAPþCD56À cells, is accompanied by the induction of the adipogenic differentiation potential and by the enhancement of the osteogenic differentiation capacity. Several reports underline the important role of CD56 expression on fibroblasts to support the growth of hematopoietic stem cells [41–43].

54] Baksh D, Zandstra PW, Davies JE. A non-contact suspension culture approach to the culture of osteogenic cells derived from a CD49elow subpopulation of human bone marrow-derived cells. Biotechnol Bioeng 2007;98:1195–208. [55] Delorme B, Ringe J, Gallay N, et al. Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells. Blood 2008;111:2631–5. [56] Odabas S, Sayar F, Guven G, et al. Separation of mesenchymal stem cells with magnetic nanosorbents carrying CD105 and CD73 antibodies in flow-through and batch systems.

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