Annual Review of Immunology Volume 21 2003 by Annual Reviews

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50:1495– 502 Vincenti F, Kirkman R, Light S, Bumgardner G, Pescovitz M, Halloran P. Neylan J, Wilkinson A, Ekberg H, Gaston R, Backman L, Burdick J. 1998. Interleukin2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. N Engl J. Med. 338:161–65 Nussenblatt RB, Fortin E, Schiffman R, Rizzo L, Smith J. vanVeldhuisen P, Sran P, Yaffe A, Goldman CK, Waldmann TA, Whitcup SM. 1999. Treatment of non-infectious intermediate and posterior uveitis with the humanized anti-Tac monoclonal antibody: a phase I/II clinical trial.

A bite from an infected mosquito transmits the malaria sporozoites into the bloodstream and eventually to the liver where they invade hepatocytes and undergo a series of rapid divisions to give rise to the merozoite stage form of the parasite. The merozoites reenter the bloodstream and invade erythrocytes, where they multiply to produce either more merozoites or gametes, which can be taken up by a feeding mosquito. SGM LaTeX2e(2002/01/18) Annu. Rev. Immunol. 21:29-70. org by HINARI on 09/01/07.

21:29-70. org by HINARI on 09/01/07. For personal use only. SGM LaTeX2e(2002/01/18) P1: FHD PAMER On the other hand, mice lacking 4-1BB ligand (4-1BBL) exhibit normal primary CD8 T cell expansion but decreased numbers of antigen-specific T cells that remain late in the primary response as well as reduced memory responses (68). This suggests that CD28 is critical for initial CD8 expansion during influenza infection, whereas 4-1BBL is needed to maintain T cell numbers later in the response that give rise to the memory pool.

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